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Methadone has comparable impacts and dangers of other narcotics like morphine, hydromorphone, oxycodone, and fentanyl. Be that as it may, it additionally has an exceptional pharmacokinetic profile. Contrasted and short-acting and surprisingly broadened discharge plans of morphine, methadone shows a similarly longer term of activity and half-life.
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Methadone may cause serious or life-threatening breathing problems, especially during the first 24 to 72 hours of your treatment and any time your dose is increased. Your doctor will monitor you carefully during your treatment. Tell your doctor if you have or have ever had slowed breathing or asthma. Your doctor will probably tell you not to take methadone
Also tell your doctor if you have or have ever had lung disease such as chronic obstructive pulmonary disease (COPD; a group of lung diseases that includes chronic bronchitis and emphysema), a head injury, a brain tumor, or any condition that increases the amount of pressure in your brain. The risk that you will develop breathing problems may be higher if you are an older adult or are weak or malnourished due to disease
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By and large, methadone’s pharmacological activities bring about absense of pain, concealment of narcotic withdrawal side effects, sedation, miosis, perspiring, hypotension, bradycardia, queasiness and heaving (through restricting inside the chemoreceptor trigger zone), and clogging. At higher portions, methadone use can bring about respiratory gloom, glut, and death.21,22,23
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By law, just a SAMHSA-guaranteed treatment program (OTP) can apportion methadone for the treatment of OUD. Patients taking methadone to treat OUD should get the drug under the oversight of an expert. After a time of soundness (in light of progress and demonstrated, predictable consistence with the medicine measurements), patients might be permitted to take methadone at home between program visits.