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sold under the brand names Numorphan and Opana among others, is an opioid pain medication. Pain relief after injection begins after about 5–10 minutes, after oral administration it begins after about 30 minutes, and lasts about 3–4 hours for immediate-release tablets and 12 hours for extended-release tablets.[4] The elimination half-life of oxymorphone is much faster intravenously, and as such, the drug is most commonly used orally.[5] Like oxycodone, which metabolizes to oxymorphone, oxymorphone has a high potential to be abused.[6] When used intravenously, heroin and morphine create a larger histamine release, resulting in the feeling of a greater subjective “body high” and more intense “rush”, but also greater instances of pruritus (itching) when compared to oxymorphone and hydromorphone. Morphine and its ester salt morphine diacetate (diamorphine or heroin) have greater addiction potential when compared to oxymorphone.[7][8]

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It was developed in Germany in 1914. It was patented in 1955 and approved for medical use in 1959.[9] In June 2017 the FDA asked Endo Pharmaceuticals to remove its product from the US market.[10] This was in part due to the opioid epidemic in the US, and the fact that a 2012 reformulation failed to stop illicit injection of the drug. Endo responded by voluntarily removing Opana ER from the market a month later.[11] Generic versions of extended-release oxymorphone, such as those manufactured by Amneal Pharmaceuticals, are still available in the US


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